Antimicrobial resistance (AMR) is a critical One Health challenge, now causing more deaths annually than malaria and HIV combined. Yet, community-led social and behaviour change (SBC) interventions to tackle AMR remain under-evaluated. The MRC-funded COSTAR (Community-Led Solutions to Antimicrobial Resistance) project tested whether the Community Dialogue Approach (CDA), a repeatable, participatory communication process, could shift antibiotic knowledge across human, animal, and environmental domains in rural Bangladesh.
A two-arm cluster-randomised trial was implemented in 50 community clinic catchments in Cumilla district, comparing communities that received 11 structured dialogues led by trained local facilitators (n=221; 50% women) against controls. Dialogues, supported by co-developed flipbooks and storytelling, encouraged reflection, shared decision-making, and collective action.
A total of 4362 dialogues were facilitated, 2289 with women, and 2073 with men. Across 80,164 attendees, 42,983 were women and 37181 were men, some participants may have attended multiple sessions, so figures reflect attendances rather than unique individuals.
Results showed statistically significant improvements in community knowledge of antibiotic use for human health (+16 percentage points (pp), p<0.001) and animal/environmental health (+12 pp, 95% CI: 5–19, p<0.001). Effects were strongest among frequent participants. Process evaluation findings demonstrated high facilitator ownership, community trust, gender-inclusive participation, and strong linkage with health structures.
These results provide the first experimental evidence that a locally owned CDA can effectively translate complex AMR concepts into community knowledge and some self-reported action.
Overall, the CDA's integration within Bangladesh's community clinic network helped institutionalise One Health engagement.